cell death — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T39849	Propargite		Parasite
	Propargite is a pesticide used to kill mites. Propargite induces β-cell necrosis preceded by DNA damage. Propargite induces MIN6 cell death with an IC 50 of 1 μM [1] .		Parasite
T8982	RH01687		Others
	RH01687 is a potent β-cell protector , exhibits β-cell-protective activities against endoplasmic reticulum (ER) stress.		Others
T4004	Concanavalin A		Apoptosis
	Concanavalin A is a plant lectin that is a T cell mitogen. It induces apoptosis in human fibroblasts.		Apoptosis
T5210	BAI1		Apoptosis , BCL
	BAI1 (Bax channel blocker) is a potent inhibitor of Bax-mediated mitochondrial cytochrome C release (IC50: 0.52 μM).		Apoptosis , BCL
T2S0820	Karanjin		Apoptosis , AMPK
	Karanjin is a flavonoid obtained from the seeds of the karanja tree.Karanjin induces GLUT4 translocation in skeletal muscle cells by increasing AMPK activity. Karanjin can induce cancer cell death through cell cycle arre...		Apoptosis , AMPK
T8922	SRS11-92	AA9	Ferroptosis
	SRS11-92 (AA9) is a ferroptosis inhibitor and a derivative of ferrostatin-1		Ferroptosis
T22026	AGK7		Others , Sirtuin
	AGK7 is an inactive control of AGK2, a selective SIRT2 inhibitor that selectively inhibits SIRT3 over SIRT1 and SIRT2 (IC50 = >5 μM, >50 μM and >50 μM for SIRT3, SIRT1, and SIRT2, respectively).		Others , Sirtuin
T10952	Dabuzalgron	Ro 115-1240	Apoptosis , Adrenergic Receptor
	Dabuzalgron (Ro 115-1240) is an orally active selective alpha-1A adrenergic receptor agonist used to treat urinary incontinence. Dabuzaron prevents cardiotoxicity caused by doxorubicin by maintaining mitochondrial functi...		Apoptosis , Adrenergic Receptor
T36964	BML-259	CAY10554	CDK
	BML-259 is an inhibitor of CDK5 and CDK2 with IC50s of 64 and 98 nM, respectively. BML-259 can be used in studies about the treatment of cancer and neurodegenerative diseases.		CDK
T21678	3MB-PP1		PLK
	3MB-PP1 is a bulky purine analog and a Polo-like kinase 1 (Plk1) inhibitor. In cells expressing analog-sensitive Plk1 alleles, 3MB-PP1 blocks mitotic progression and cell division arise by targeting Plk1. 3MB-PP1 specifi...		PLK
T5827	BI-6C9		Apoptosis , Others , Mitochondrial Metabolism
	BI-6C9 is an inhibitor of tBid (Kd = 20 µM).BI-6c9 prevented MOMP and mitochondrial fission, and protected the cells from cell death.		Apoptosis , Others , Mitochondrial Metabolism
T4517	L189		DNA , DNA/RNA Synthesis
	L189 is a human DNA ligase inhibitor, inhibits hLigI/III/IV (IC50: 5/9/5 μM).		DNA , DNA/RNA Synthesis
T6500	Ferrostatin-1	Ferrostatin 1,Ferrostatin-1 (Fer-1)	Ferroptosis , Antifungal
	Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of iron death. Ferrostatin-1 potently inhibits Erastin-induced iron death in HT-1080 cells with an EC50 of 60 nM. Ferrostatin-1 also exhibits antioxidant and anti...		Ferroptosis , Antifungal
T21463	Temozolomide Acid	TMZA	Others
	Temozolomide Acid (TMZA) is a metabolite of temozolomide (TMZ). Temozolomide processes anticancer activity in vitro. Temozolomide (TMZ) is an oral alkylating agent used to treat glioblastoma multiforme (GBM) and astrocyt...		Others
T12472	Pifithrin-α, p-Nitro, Cyclic	PFN-α	p53
	Pifithrin-α, p-Nitro, Cyclic (PFN-α) (PFN-α) is cell-permeable and active-form inhibitor of p53.		p53
T6485	Embelin	NSC 91874,Emberine,Embelic acid	Apoptosis , NF-κB , Lipoxygenase , IAP , Prostaglandin Receptor , Autophagy
	Embelin (Embelic acid), isolated from the Japanese Ardisia herb, is an inhibitor of the X-linked inhibitor of apoptosis (IC50: 4.1 uM).
T12617L	(R)-CR8	(R)-CR8,(R)-Isomer,CR8	Apoptosis , CDK
	(R)-CR8 ((R)-Isomer) is a potent and selective CDK inhibitor.		Apoptosis , CDK
T12906	SI-2 hydrochloride	EPH 116 hydrochloride	Src
	SI-2 hydrochloride (EPH 116 hydrochloride) is a highly promising inhibitor of SRC-3 SMI: SRC-3 (PPI)(IC50 values of 3-20 nM for breast cancer cell death), with acceptable oral availability.		Src
T17192	Ubiquitin Isopeptidase Inhibitor I, G5	NSC144303	Apoptosis
	Ubiquitin Isopeptidase Inhibitor I, G5 is a caspase-independent inducer of cell necrosis that induces cell death via the death receptor pathway (IC50 of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively).		Apoptosis
T8468	CIL62		Caspase
	CIL62 is a caspase-3/7-independent inducer of cell death. The mechanism of action of CIL62 is Necrostatin-1 dependent cell death [1].		Caspase